MiniFAB Showcase
Micro-Engineered Solutions for Complex Problems
MiniFAB is currently developing and manufacturing customised microfluidic solutions for its global clients in the area of point of care diagnostics, lab-on-chip microfluidics and medical devices.
Projects include immuno and protein diagnostics for point of care applications; “sample to answer” molecular diagnostics for point of care applications, sample preparation modules for cell/bead applications; Smart implants for medical devices, to name a few.
Below are some examples from our MiniFAB Showcase.
Eye Disease Diagnostics Nanofluidic Point of Care Biosensor
Key Project Achievements
- Analysis of ocular disorder by sampling and analysing 50nL of tear fluid
- MiniFAB developer and manufacturer
- Full product development less than 2 years
- Current production 1M units/pa
Cancer Diagnostics Point of Care
Key Project Achievements
- Point of care biosensor system for cancer diagnosis
- SmartHEALTH EU 6th Framework Integrated Project
- On-board assay reagents, MEMs biosensor
- Integration of microfluidic metering, valves, mixers
Molecular Diagnostics Point of Care and Laboratory
Key Project Achievements
- Microfluidic cartridges for sample preparation and molecular diagnostics
- "Sample to answer" cartridges integrating sample preparation, amplification and detection
- Reduced reagent volumes
- Reduced time to result
Environmental Monitoring In-Field River Water Quality Control
Fast Monitoring of E.Coli in Field
Design Brief
Design and development of a rapid, cost effective and automatic detection system for E.coli in water, including:
- Biosensor cartridge
- Concentrator
- Instrumentation (including assay reagent management system)
Project Outcomes
- Designed, developed disposable microfluidic cartridges with integrated electrochemical biosensors
- Bench-top assay (enzymatic depletion assay) transferred to microfluidic cartridge
- Engineering of the biosensor platform interface with the concentrator
- System integration of the biosensor platform, concentrator and instrument
- Established CDP System for Client
Food Diagnostics Detection of Toxins in Milk
Immuno Biosensor System for Diagnostics
Design Brief
- Development of a biosensor platform for the rapid, accurate and automatic detection of contaminates in milk
- User scenarios: point of collection (i.e. farm), milk processing site or at milk-product manufacturing site
- Establish initial technical feasibility of the biosensor platform for the detection of a variety of different target species in milk
Project Outcomes
- Designed, developed disposable microfluidic cartridges with integrated electrochemical biosensors
- Transfers bench top ELISA competitive assay for Aflatoxin M1 onto microfluidic platform
- Production of cartridge for small pre-clinical test series (1000 units)
- MiniChemLAB Microfluidic Workstation Prototype Instrument
- Demonstrated detection of Aflatoxin M1 in raw milk for Client with high sensitivity, excellent dynamic range (0 to 2000ppt) and time to result < 5 minutes
Bionic Eye
- Outside glasses – digital camera
- Inside glasses – eye movement sensor will direct the camera
- Side of glasses – digital processor and wireless transmitter
- Brain implant – small implant under the skull will receive wireless signals and directly stimulate the brain's visual cortex
Monash Vision Direct to Brain Bionic Eye
- 4 year Australian Research Council funded Development Program
- Electrical micro-stimulation of the V1 visual cortex
MiniFAB's Role
- Design and fabrication of implant
- Design and fabrication of surgical tool (to assist implant surgery)
- Guidance to the regulatory framework (ISO13485 compliance)
